一、简介：

李为，女，宁夏医学院医疗系临床医学学士，南卡罗来纳大学公共卫生学院生物统计学硕士，明尼苏达大学医学院医学系风湿病科博士后研究员，南卡罗来纳大学医学院内分泌、糖尿病和代谢科博士后研究员。曾为宁夏医学院免疫学研究室助教、讲师，西安医科大学（现西安交通大学）分子病毒研究所、湖南医科大学（现中南大学）肿瘤分子生物学癌症研究所、北京医科大学人民医院血液学研究所访问学者，汕头大学肿瘤医院骨髓移植中心主治医师、骨髓移植临床实验室负责人，明尼苏达大学医学院医学和细胞生物学及神经解剖学系、内分泌、糖尿病和代谢科志愿者研究员，明尼苏达大学医学院医学系风湿病科博士后研究员，南卡罗来纳大学医学院内分泌、糖尿病和代谢科博士后研究员，南卡罗来纳大学医学院、细胞生物学和神经科学系助理教授，埃默里大学医学院精神病学和行为科学系分子精神病学研究实验室研究员，埃默里大学医学院心脏内科、亚特兰大退伍军人医疗中心-心血管遗传研究室高级研究员、UL Med. Inc, USA、UL CELL THERAPEUTIC PTE.LTD.技术总监等。

二、主持的主要科研项目、发表的代表论文及专利

1. Christina Caruso, Wei Li, David Myers, Clinton Joiner, and Wilbur Lam. Less Deformable Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease, Blood Manuscript # BLD-2024-024608R1 Date August 4, 2024

2. Oluwabukola T Gbotosho , Wei Li, Clinton H Joiner, Lou Ann S Brown , Hyacinth I Hyacinth, The inflammatory profiles of pulmonary alveolar macrophages and alveolar type 2 cells in SCD. Exp Biol Med (Maywood) Volume: 248 Page(s): 1013 – 1023, 06/01/2023

3. Christina Caruso, Wei Li, Clinton H. Joiner, Wilbur A. Lam, MD PhD. Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease. Blood (2019) 134: 3560.

4. Yichen Wang, Wei Li, Clinton H. Joiner, Wilbur A Lam, Vessel Geometry Interacts with Red Blood Cell Stiffness to Promote Endothelial Dysfunction in Sickle Cell Disease. Blood (2015) 126 (23): 965.

5. Caryn S Gonsalves; Scott Crable; Sharat Chandra; Wei Li; Vijay K Kalra; Clinton Joiner Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α. American Journal of Hematology, (2014) Volume 89, Number 3, Pages 273-281

6. Blanco RR, Austin H, Vest RN 3rd, Valadri R, Li W, Lassegue B, Song Q, London B, Dudley SC, Bloom HL, Searles CD, Zafari AM. Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure.J Card Fail. 2012 Sep;18(9):717-23. doi: 10.1016/j.cardfail.2012.06.531. Epub 2012 Aug 9. PMID: 22939041

7. Dikalov SI, Li W, Doughan AK, Blanco RR, Zafari AM. Mitochondrial reactive oxygen species and calcium uptake regulate activation of phagocytic NADPH oxidase. Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1134- 42. doi: 10.1152/ajpregu.00842.2010. Epub 2012 Mar 21.

8. Charles D Searles Jr.; A. Maziar Zafari, Angiotensin Receptor Type 1 Single Nucleotide Polymorphism A1166C is Associated with Malignant Arrhythmias and Altered Circulating miR-155 Levels in Patients with Chronic Heart Failure, Journal of Cardiac Failure, Volume 18, Number 9, 2012-09, Pages 717-723

9. Zuo L, Li W, You S*. Progesterone reverses the mesenchymal phenotypes of basal phenotype breast cancer cells via a membrane progesterone receptor mediated pathway. Breast Cancer Research, 2010, 12: R34 (11 June 2010).

10. You S*, Zuo L, Li W. Optimizing the Time of Doxil Injection to Increase the Drug Retention in Transplanted Murine Mammary Tumors. International Journal of Nanomedicine. 2010:5, 221-9. PMID: 20463938.

11. Mehranpour P, Wang SS, Blanco RR, Li W, Song Q, Lassègue B, Dikalov SI, Austin H, Zafari AM. The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):251-9. doi: 10.2174/187152509789105417.PMID: 19689263

12. Menranpour P; Austin H; Wang S; Lassegue B; Song Q; Li W; Hooper C; Zafari AM, Nox1 promoter polymorphism is associated with coronary artery disease and myocardial infarction, Volume: 51 Page(s): A343 - A343. 03/11/2008

13. Wang SS, Tondella ML, Bajpai A, Mathew AG, Mehranpour P, Li W, Kac harava AG, Fields BS, Austin H, Zafari AM. Circulating Chlamydia pneumoniae DNA and advanced coronary artery disease.Int J Cardiol. 2007 May 31;118(2):215-9. doi: 10.1016/j.ijcard.2006.07.013. Epub 2006 Oct 4.

14. Dikalov SI, Li W, Mehranpour P, Wang SS, Zafari AM. Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay. Biochem Pharmacol. 2007 Apr 1;73(7):972-80.

专利

编号：1009192.103W02-PCT（Pending）

编号：1009192.103US2-USA（Pending）

编号：1009192.100US2 -USA 获授权

编号：1009192.102US0 -USA 获授权